{"id":434,"date":"2015-04-21T08:01:58","date_gmt":"2015-04-21T00:01:58","guid":{"rendered":"http:\/\/www.lac.tcu.edu.tw\/?page_id=434"},"modified":"2022-10-04T17:10:26","modified_gmt":"2022-10-04T09:10:26","slug":"%e5%b0%8f%e9%bc%a0","status":"publish","type":"page","link":"https:\/\/lac.tcu.edu.tw\/?page_id=434","title":{"rendered":"\u5be6\u9a57\u5c0f\u9f20 (laboratory mouse)"},"content":{"rendered":"

\u4e00\u3001\u00a0 \u4f7f\u7528\u91cf\u6700\u591a\u7684\u7269\u7a2e<\/strong><\/p>\n

\u64da2000\u5e74Science (288: 248-57) \u5831\u5c0e\uff0c\u5728\u5be6\u9a57\u5c0f\u9f20\u7684\u4f7f\u7528\u4e0a\uff0c\u5168\u7403\u6bcf\u5e74\u5df2\u8d85\u904e25,000,000\u96bb\uff0c\u8f031980\u5e74\u4ee3\u5df2\u591a\u4e862\u500d\uff0c\u4e14\u4f54\u4e86\u6240\u6709\u79d1\u5b78\u76ee\u7684\u61c9\u7528\u4e4b\u54fa\u4e73\u52d5\u7269\u768490% \u4ee5\u4e0a\u3002\u662f\u7576\u4eca\u4f7f\u7528\u91cf\u6700\u5927\uff0c\u4e14\u54c1\u7cfb\u8207\u65cf\u7fa4\u7686\u6700\u591a\u4e4b\u7269\u7a2e\u3002
\n\u5c0f\u9f20\u4e4b\u6240\u4ee5\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u79d1\u5b78\u76ee\u7684\uff0c\u9664\u56e0\u5176\u70ba\u7576\u4eca\u5e38\u898b\u4e4b\u5be6\u9a57\u52d5\u7269\u4e2d\uff0c\u6700\u7b26\u5408\u5be6\u9a57\u52d5\u7269\u6a21\u5f0f\u689d\u4ef6\u8005\uff1b\u4e5f\u7531\u65bc\u5176\u70ba\u6700\u91cd\u8981\u7684\u907a\u50b3\u5de5\u7a0b\u52d5\u7269\u6a21\u5f0f\uff0c\u6545\u5728\u723e\u5f8c\u768410\u5e74\uff0c\u5176\u4f7f\u7528\u91cf\u61c9\u4ecd\u6703\u7e7c\u7e8c\u4ee5\u6bcf\u5e74\u589e\u52a010-20% \u7684\u901f\u7387\u6500\u5347\u3002<\/p>\n

\u4e8c\u3001\u00a0 \u52ff\u7528\u4e8c\u540d\u6cd5\u7a31\u4e4b<\/strong><\/p>\n

\u5be6\u9a57\u7528\u5c0f\u9f20\u6e90\u65bc\u5bb6\u9f20\u5c6c (Mus)\uff0c\u56e0\u572820\u4e16\u7d00\u521d\u5927\u91cf\u80b2\u7a2e\u7684\u904e\u7a0b\uff0c\u61c9\u7528\u4e86\u81f3\u5c112\u7269\u7a2e (M. musculus\u8207M. domesticus)\u3002\u73fe\u4eca\u4f7f\u7528\u7684\u5be6\u9a57\u5ba4\u5c0f\u9f20\u591a\u5df2\u7121\u6cd5\u8003\u8b49\u5176\u539f\u59cb\u4f86\u6e90\uff0c\u6545\u570b\u969b\u907a\u50b3\u54c1\u7cfb\u5c0f\u9f20\u6a19\u6e96\u5316\u547d\u540d\u59d4\u54e1\u6703 (International Committee on Standardized Genetic Nomenclature for Mice) \u5efa\u8b70\u6240\u6709\u5c0f\u9f20\u4e4b\u79d1\u5b78\u61c9\u7528\uff0c\u9664\u975e\u78ba\u77e5\u4f7f\u7528\u5c0f\u9f20\u4e4b\u7269\u7a2e\uff0c\u52ff\u7528\u4e8c\u540d\u6cd5\u8868\u793a\uff0c\u800c\u76f4\u63a5\u4ee5\u5c0f\u9f20\u4e4b\u54c1\u7cfb\u6216\u65cf\u7fa4\u540d\u7a31\uff1b\u6216\u76f4\u63a5\u7a31\u4e4b\u70ba\u5be6\u9a57\u5c0f\u9f20 (laboratory mouse)\u3002<\/p>\n

\u4e09\u3001\u00a0 \u5c0f\u9f20\u4e4b\u6210\u9577<\/strong><\/p>\n

\u5c0f\u9f20\u51fa\u751f\u6642\u4e4b\u9ad4\u91cd\u7d041.0-2.0 gm\uff0c\u800c\u4f9d\u65cf\u7fa4\u6216\u54c1\u7cfb\u4e4b\u4e0d\u540c\uff0c\u5176\u6210\u9577\u901f\u7387\u6709\u4e9b\u5fae\u5dee\u7570\uff0c\u800c\u6210\u9f20\u4e4b\u9ad4\u91cd\u4e5f\u4f9d\u65cf\u7fa4\u6216\u54c1\u7cfb\u6709\u6240\u5dee\u7570 (\u5be6\u9a57\u5c0f\u9f20\u3001\u5be6\u9a57\u5927\u9f20\u8207\u6558\u5229\u4e9e\u5009\u9f20\u4e4b\u57fa\u672c\u751f\u9577\u8207\u751f\u6b96\u6027\u72c0\u8868<\/a>\u3001\u57161)<\/span> \u3002<\/p>\n

\u57161\u70ba\u672c\u6821\u52d5\u7269\u4e2d\u5fc3\u7e41\u6b96\u4e4bMF-1\u8207NMRI\u5c0f\u9f20\u4e4b\u6210\u9577\u3002MF-1\u70ba\u9022\u6a5f\u65cf\u7fa4\u5c0f\u9f20 (random bred stock)\uff0c\u800c\u8207NMRI\u5c0f\u9f20\u70ba\u7d93\u8fd1\u89aa\u54c1\u7cfb\u80b2\u7a2e\uff0c\u9023\u7e8c\u5144\u59b9\u4ea4\u914d\u5230\u7b2c16\u4ee3\uff0c\u4f46\u5728\u5c1a\u672a\u5b8c\u6210\u80b2\u7a2e\u7a0b\u5e8f\uff0c\u5373\u4ee5\u9022\u6a5f\u65cf\u7fa4\u7684\u65b9\u5f0f\u7e8c\u4ee3\u3002\u9019\u4e8c\u65cf\u7fa4\u4e4b\u7e41\u6b96\u529b\u7686\u4f73\uff0c\u6210\u9f20\u4e4b\u9ad4\u578b\u8f03\u4e00\u822c\u8fd1\u89aa\u54c1\u7cfb\u70ba\u5927\uff0c\u4e5f\u5982\u540c\u6240\u6709\u5c0f\u9f20\uff0c\u96c4\u9f20\u7686\u8f03\u96cc\u9f20\u5927 \u3002<\/p>\n

\"\"<\/a>
\n\u57161. MF-1\u8207NMRI\u5c0f\u9f20\u4e4b\u589e\u91cd (mean \u00b1 std)\u3002 (\u53ef\u9ede\u5716\u653e\u5927)<\/span><\/span><\/p>\n

*MF-1\u5c0f\u9f20\u4e4b\u6578\u64da\u5f97\u81ea6\u80ce\u5c0f\u9f20\uff0c\u6bcf\u80ce\u4ed4\u6578\u70ba11-14\u96bb\uff0c\u800c\u7a2e\u9f20\u4ee5\u4e00\u96c4\u4e00\u96cc\u4e4b\u6c38\u4e45\u914d\u5c0d\u6cd5 (permanent monogamy) \u914d\u7a2e\uff0c\u9019\u4e9bMF-1\u5c0f\u9f20\u7686\u70ba\u96cc\u7a2e\u9f20\u6240\u751f\u80b2\u4e4b\u7b2c3-5\u80ce\u3002\u96e2\u5976\u524d (\u81f33\u9031\u9f61)\uff0c\u50c5\u4ee5\u6574\u80ce\u79e4\u4e4b\uff0c\u96e2\u5976\u5f8c\u5247\u6bcf\u96bb\u91cf\u79e4\uff1b\u65bc\u7e41\u6b96\u8207\u6e2c\u91cf\u671f\u9593\uff0c\u98fc\u6599\u4ee5PMI Laboratory Rodent Diet 5001\u4efb\u98fc (ad libitum)\uff1b\u98f2\u6c34\u4ee5RO\u6c34\uff1b\u98fc\u80b2\u7c60\u5247\u4ee5\u978b\u76d2\u578b\u7c60\u52a0\u6ffe\u7db2\u84cb (micro-isolator)\u3002NMRI\u5c0f\u9f20\u5247\u5f97\u81ea\u96cc\u3001\u96c4\u9f20\u54045\u96bb\u4e4b\u6578\u64da\u3002\u81ea1\u9031\u9f61\u8d77\uff0c\u7531\u5206\u5c6c5\u80ce\u4e4b\u96cc\u3001\u96c4\u5c0f\u9f20\u5404\u4e00\uff0c\u9023\u7e8c\u79e4\u91cd\u81f38\u9031\u9f61\u3002\u6e2c\u91cf\u671f\u9593\uff0c\u98fc\u6599\u4ee5PMI Laboratory Autoclavable Rodent Diet 5010\uff1b\u800c\u98f2\u6c34\u4ee5\u7d93\u9ad8\u6eab\u6ec5\u83cc\u4e4bRO\u6c34\uff1b\u98fc\u80b2\u7c60\u5247\u4ee5IVC (individual ventilated cage)\u3002<\/span><\/p>\n

\u56db\u3001\u00a0 \u5c0f\u9f20\u4e4b\u4fb5\u7565\u6027\u8207\u98fc\u80b2<\/strong><\/p>\n

\u570b\u969b\u6a19\u6e96\u5316\u98fc\u80b2\u5be6\u9a57\u5c0f\u9f20\u7684\u65b9\u5f0f\uff0c\u5373\u672c\u6821\u52d5\u7269\u4e2d\u5fc3\u76ee\u524d\u4f7f\u7528\u7684\u65b9\u5f0f\u3002\u5728\u98fc\u80b2\u5bb6\u9f20\u5c6c\u52d5\u7269\u6642\uff0c\u61c9\u5148\u77ad\u89e3\u5b83\u5011\u7684\u884c\u70ba\u7279\u6027\u3002\u4ee5\u4e0b\u4ee52\u96c4\u5c0f\u9f20\u4e4b\u884c\u70ba\u7279\u5fb5\u70ba\u4f8b<\/p>\n

    \n
  1. \u96c4\u6027\u5c0f\u9f20\u9593\u4e4b\u4fb5\u7565\u6027 (inter-male aggression) \u70ba\u5176\u884c\u70ba\u7279\u5fb5\u4e4b\u4e00\u3002\u5bb6\u9f20\u5c6c\u70ba\u793e\u7fa4\u52d5\u7269\uff0c\u5728\u91ce\u5916\u591a\u70ba\u5c0f\u65cf\u7fa4\uff0c\u9019\u8207\u737c\u7334 (Macaca sp) \u985e\u4f3c\uff0c\u7531\u4e00\u96c4\u9f20\u70ba\u300c\u9996\u9818 (dominant male; \u03b1-male)\u300d\u4e3b\u5c0e\u65cf\u7fa4\u4e4b\u548c\u8ae7\uff0c\u65cf\u7fa4\u4e2d\u4e4b\u96cc\u9f20\u591a\u70ba\u03b1-\u96c4\u9f20\u4e4b\u59bb\u59be\uff0c\u5176\u5b83\u96c4\u5c0f\u9f20 (subordinate) \u5728\u6210\u9577\u5f8c\u6216\u96e2\u958b\u65cf\u7fa4\uff1b\u6216\u5728\u300c\u6070\u7576\u6642\u6a5f\u300d\u6311\u6230\u03b1-\u96c4\u9f20\uff0c\u671f\u53d6\u800c\u4ee3\u4e4b (\u898bBruce effect)\u3002\u6545\u5728\u98fc\u80b2\u7c60\u5bc6\u96c6\u7fa4\u98fc\u96c4\u5c0f\u9f20\u4e0b\uff0c\u96c4\u9f20\u9054\u6027\u6210\u719f\u5f8c\u5e38\u6703\u6253\u67b6\uff0c\u4e14\u5e38\u6253\u5230\u53ea\u5269\u4e00\u96bb\u5b58\u6d3b\u3002\u518d\u8005\uff0c\u7576\u4e00\u6027\u6210\u719f\u96c4\u9f20\u5728\u55ae\u7368\u98fc\u80b2\u65bc\u4e00\u98fc\u80b2\u7c60\uff1b\u6216\u8207\u96cc\u9f20\u5171\u98fc\u65bc\u4e00\u98fc\u80b2\u7c60\u5f8c\uff0c\u82e5\u5c07\u4e4b\u8207\u5176\u4ed6\u96c4\u9f20\u5171\u98fc\uff0c\u4e5f\u6703\u51f6\u6027\u5927\u767c\u3002<\/li>\n
  2. \u7528\u65bc\u7e41\u6b96\u4e4b\u96c4\u9f20\uff0c\u9664\u975e\u4e00\u76f4\u8207\u96cc\u7a2e\u9f20\u5171\u98fc\uff0c\u5426\u5247\u82e5\u5728\u4ea4\u5abe\u5f8c\uff0c\u99ac\u4e0a\u9047\u898b\u525b\u51fa\u751f\u4e4b\u4ed4\u9f20 (neonate)\uff0c\u4e5f\u6703\u5927\u767c\u51f6\u6027\u5730\u6bba\u5b30 (infanticide)\uff0c\u82e5\u9019\u96c4\u9f20\u65bc3\u9031\u5167\u4e0d\u518d\u4ea4\u914d\uff0c\u5247\u9019\u51f6\u6b98\u7684\u6bba\u5b30\u884c\u70ba\u6703\u5728\u4ea4\u914d\u5f8c3\u9031\u8f49\u70ba\u898b\u65b0\u751f\u4ed4\u5373\u300c\u4fdd\u8b77\u300d\u7684\u7236\u89aa\u884c\u70ba (paternal behavior)\u3002\u672c\u884c\u70ba\u7279\u5fb5\u5df2\u88ab\u55bb\u70ba\u5929\u64c7 (natural selection) \u4e2d\u7684\u81ea\u79c1\u9078\u64c7 (selfish selection)\u3002\u4e5f\u66fe\u88ab\u61c9\u7528\u65bc\u89e3\u91cb\u9ed1\u7329\u7329\u793e\u7fa4\u7684\u985e\u4f3c\u884c\u70ba\uff1b\u5373\u7576\u4e00\u96cc\u9ed1\u7329\u7329\u5e36\u8457\u54fa\u80b2\u4e2d\u7684\u5c0f\u7329\u7329\uff0c\u6295\u9760\u4e00\u65b0\u65cf\u7fa4\u6642\uff0c\u65b0\u65cf\u7fa4\u7684\u96c4\u6027\u9ed1\u7329\u7329\u6703\u5148\u5c07\u5176\u5b50\u6bba\u6b7b\uff0c\u8a72\u96cc\u6027\u9ed1\u7329\u7329\u624d\u6703\u88ab\u65b0\u65cf\u7fa4\u63a5\u53d7\u3002<\/li>\n<\/ol>\n

    \u6545\u5728\u98fc\u80b2\u5be6\u9a57\u5c0f\u9f20\u6642\uff0c\u81ea\u5be6\u9a57\u8a2d\u8a08\u81f3\u98fc\u990a\u7ba1\u7406\uff0c\u7686\u61c9\u8003\u91cf\u4e0a\u8ff0\u96c4\u6027\u5c0f\u9f20\u4e4b\u4fb5\u7565\u6027\u884c\u70ba\u7279\u5fb5\uff0c\u907f\u514d\u56e0\u7121\u77e5\u800c\u7522\u751f\u4e0d\u4eba\u9053\u7684\u7d50\u679c\u3002<\/p>\n

    \u4e94\u3001\u00a0 \u96e2\u5976\u5e74\u7d00\u4e4b\u5c0f\u9f20\u975e\u5e38\u6d3b\u6f51<\/strong><\/p>\n

    \u5728\u672c\u6821\u52d5\u7269\u4e2d\u5fc3\u53e6\u4e00\u5e38\u767c\u751f\u7684\u5c0f\u9f20\u554f\u984c\uff0c\u70ba\u6253\u958b\u5feb\u96e2\u4e73\u4e4b\u5c0f\u9f20\u98fc\u80b2\u7c60\u6642\uff0c\u9019\u4e9b\u7d043\u9031\u9f61\u7684\u5c0f\u9f20\u8df3\u4e86\u6eff\u5730\uff0c\u53c8\u5e38\u56e0\u8a18\u9304\u4e0d\u660e\uff0c\u800c\u4e0d\u77e5\u662f\u5426\u5c07\u6240\u6709\u9003\u812b\u7684\u5c0f\u9f20\u6293\u56de\u3002\u9019\u4e5f\u53ef\u7b97\u662f\u5c0f\u9f20\u4e4b\u884c\u70ba\u7279\u5fb5\uff0c\u7576\u5176\u9054\u96e2\u4e73\u4e4b\u5e74\u7d00\u6642\uff0c\u975e\u5e38\u559c\u6b61\u8df3\u8e8d\uff0c\u53c8\u671f\u63a2\u7d22\u300c\u5de2\u300d\u5916\u7684\u74b0\u5883\uff0c\u6545\u4e5f\u8acb\u540c\u4ec1\u8207\u540c\u5b78\u61c9\u7279\u52a0\u6ce8\u610f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u4e00\u3001\u00a0 \u4f7f\u7528\u91cf\u6700\u591a\u7684\u7269\u7a2e \u64da2000\u5e74Science (288: 248-57) … \u95b1\u8b80\u5168\u6587 →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-434","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=434"}],"version-history":[{"count":2,"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/434\/revisions"}],"predecessor-version":[{"id":2301,"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/434\/revisions\/2301"}],"wp:attachment":[{"href":"https:\/\/lac.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}